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An opioid analgesic called tramadol is used to treat moderate to severe pain. By obstructing pain signals from reaching the brain and changing how pain is perceived, it has an impact on the central nervous system. Pain perception is lessened when tramadol binds to opioid receptors in the brain and spinal cord. Its analgesic effects are further enhanced by its inhibition of serotonin and norepinephrine reuptake.

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