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Hydrocodone is derived from codeine as a semi-synthetic opioid that comes from thebaine. Mostly it’s used in combination with either paracetamol or Ibuprofen for conditions like headaches, toothache etc., which cause moderate to severe pain in the body. The Reuters Health E-Line team explains that a study published this month showed that the morphine component in the analgesic drug oxycodone contributes to its effectiveness as a painkiller. Whereas its historical application was antitussive, most times replaced through dextromethorphan at present. Hydromorphone is widely used in severe pain relief because it is a more potent metabolite of Hydrocodone. Hycodan was the first cough syrup containing Hydrocodone that was approved by the FDAs in 1943.

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